I have a dual monitor set-up and, as such, I have 200% scaling on my primary screen (13 inch up to 4k) and 100% scaling on my second monitor.

Example:

#!/bin/sh
sudo xrandr --output DP-1 --off
sudo xrandr --output eDP-1 --primary --mode 3456x2160 --pos 0x0 --rotate normal --scale 0.9999x0.9999 --output DP-1 --mode 1920x1080 --pos 3456x0 --rotate normal --scale 2x2 --output HDMI-1 --off --output DP-2 --off --output DP-3 --off --output DP-4 --off

#randr --output eDP-1 --primary --mode 3456x2160 --pos 0x0 --rotate normal --scale 0.9999x0.9999 --output DP-1 --mode 1920x1080 --pos 3456x0 --rotate normal --scale 2x2 -r 59.94 --output HDMI-1 --off --output DP-2 --off --output DP-3 --off --output DP-4 --off

#!/bin/bash
DEVICE=$1
if [ "$1" == "" ] ; then
    DEVICE="DP-1"
fi
MODELINE=\"$(cvt 1920 1080 | grep -e "^#" -v | cut -d '"' -f 2-)
MODENAME=$(echo $MODELINE | cut -d " " -f 1)
MODEPARAMS=$(echo $MODELINE | cut -d " " -f 2-)
sudo xrandr --newmode $MODENAME $MODEPARAMS
sudo xrandr --addmode $DEVICE $MODENAME

xrandr –output DP-1 –off # for after setting you have the correct wallpaper format on secondary screen
–scale 0.9999×0.9999 on eDP-1 #for disableing flickering mouse
–scale 2×2 -r 59.94 # for secondary monitor 1920×1080